The Office of Public Health Nursing comprises registered nurses who provide myriad preventive and educational services to the Worcester community. Public health nursing promotes and protects the health of populations using knowledge from the nursing, social and public health sciences. The public health nurse partners with communities, organizations, and populations to reduce health risks and to promote, maintain, and restore health, as well as, to advocate for system-level changes to improve health.

The Public Health Nursing Office offers Tuberculosis testing and treatment clinics in conjunction with Family Health Center of Worcester and UMASS Memorial Healthcare. It also provides Direct Observed Therapy to patients on Tuberculosis medications.
The nurses are also responsible for the investigation and follow up of all reportable, communicable diseases. Investigation may involve a visit to the patient's home, a telephone call and/or a follow up letter.
The Worcester Senior Center's Health and Wellness clinic is staffed by one full time Public Health nurse. Staff nurses also participate in blood pressure, podiatry, and influenza clinics, among others.
Public Health also provides one nurse who attends a bi-weekly clinic at eight of fourteen sites operated by the Worcester Housing Authority. The nurse provides general wellness checks, consults with doctors, and makes referrals as appropriate.